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 Table of Contents    
Year : 2012  |  Volume : 44  |  Issue : 1  |  Page : 140-141

Authors' reply

1 Department of Pharmacology, Government Medical College, Nagpur, Maharashtra, India
2 Department of Pharmacology, VCSG GMSRI, Srinagar, Pauri Garhwal, Uttarakhand, India

Date of Web Publication14-Jan-2012

Correspondence Address:
Vijay Thawani
Department of Pharmacology, VCSG GMSRI, Srinagar, Pauri Garhwal, Uttarakhand
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Source of Support: None, Conflict of Interest: None

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How to cite this article:
Bajait C, Thawani V. Authors' reply. Indian J Pharmacol 2012;44:140-1

How to cite this URL:
Bajait C, Thawani V. Authors' reply. Indian J Pharmacol [serial online] 2012 [cited 2022 Jan 24];44:140-1. Available from: https://www.ijp-online.com/text.asp?2012/44/1/140/91892


The mechanism of action of zinc to inhibit ion transport as mentioned by you [1] is based on the report published in Jan 2011. [2] This was after our paper was sent for publication. [3] However, the facts mentioned in our paper are based on the literature available that time. We accept the new findings mentioned by you that are supported by the new published literature.

Regarding the efficacy of zinc based on the etiological factor, we would like to clarify that we did not take into consideration the etiological factors but discussed in general the beneficial effects of zinc in diarrhea. Even otherwise clinically it is not always possible to establish the causative organism and treatment cannot be withheld till reports of laboratory investigations are available. Further, WHO has recommended that zinc supplements should be administered in diarrhea from the day of onset of symptoms along with ORS. [4]

We agree to the probable reasons proposed by you as far as the differential effects of zinc in diarrhea are concerned as no published study has investigated the efficacy of zinc in zinc-deficient state.

  References Top

1.Das RR. Zinc in acute childhood diarrhea: Is it universally effective? Indian J Pharmacol 2012;44:140.  Back to cited text no. 1
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2.Berni Canani R, Buccigrossi V, Passariello A. Mechanisms of action of zinc in acute diarrhea. Curr Opin Gastroenterol 2011;27:8-12.  Back to cited text no. 2
3.Bajait C, Thawani V. Role of zinc in pediatric diarrhea. Indian J Pharmacol 2011;43:232-5.  Back to cited text no. 3
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4.WHO/UNICEF Joint Statement-Clinical management of acute diarrhoea. (WHO/FCH/CAH/04.07). Geneva and New York: World Health Organization and United Nations Children's Fund; 2004.  Back to cited text no. 4


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