| RESEARCH ARTICLE
|Year : 2011 | Volume
| Issue : 2 | Page : 180-182
Lantana montevidensis Briq improves the aminoglycoside activity against multiresistant Escherichia coli and Staphylococcus aureus
Erlanio O Sousa1, Thiago S Almeida1, Fabíola F.G. Rodrigues1, Adriana R Campos2, Sidney G Lima3, José G.M. Costa1
1 Molecular Bioprospection Postgraduation Program, Laboratory of Natural Products Research, Regional University of Cariri, 63105 - 000, Crato, CE, Brazil
2 Vice-Reitoria de Pesquisa e Pós-Graduação, Universidade de Fortaleza, Av. Washington Soares 1321, Edson Queiroz, 60811-905, Fortaleza-CE, Brazil
3 Departamento de Química, Universidade Federal do Piauí, Campus Universitário Ministro Petrônio Portella, 64049-550, Bairro Ininga,Teresina-PI, Brazil
Objective : In this work, we report the antibacterial and modulatory activity of Lantana montevidensis Briq.
Materials and Methods : The antibacterial activities of leaf (LELm) and root (RELm) extracts alone or in association with aminoglycosides were determined by a microdilution test. Multiresistant strains of Escherichia coli (Ec 27) and Staphylococcus aureus (Sa 358) were used.
Results : The results show the inhibitory activity of LELm against E. coli (minimal inhibitory concentration [MIC] 16 μg/mL) and S. aureus (MIC 128 μg/mL). The synergistic effect of the extracts and aminoglycosides was verified too. The maximum effects were obtained with RELm with gentamicin against E. coli with MIC reduction (312 to 2 μL).
Conclusion : The data from this study are indicative of the activity antibacterial of extracts of L. montevidensis and its potential in modifying the resistance of aminoglycosides.
José G.M. Costa
Molecular Bioprospection Postgraduation Program, Laboratory of Natural Products Research, Regional University of Cariri, 63105 - 000, Crato, CE
Source of Support: None, Conflict of Interest: None
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