| RESEARCH ARTICLE |
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| Year : 2011 | Volume
: 43
| Issue : 2 | Page : 180-182 |
Lantana montevidensis Briq improves the aminoglycoside activity against multiresistant Escherichia coli and Staphylococcus aureus
Erlanio O Sousa1, Thiago S Almeida1, Fabíola F.G. Rodrigues1, Adriana R Campos2, Sidney G Lima3, José G.M. Costa1
1 Molecular Bioprospection Postgraduation Program, Laboratory of Natural Products Research, Regional University of Cariri, 63105 - 000, Crato, CE, Brazil
2 Vice-Reitoria de Pesquisa e Pós-Graduação, Universidade de Fortaleza, Av. Washington Soares 1321, Edson Queiroz, 60811-905, Fortaleza-CE, Brazil
3 Departamento de Química, Universidade Federal do Piauí, Campus Universitário Ministro Petrônio Portella, 64049-550, Bairro Ininga,Teresina-PI, Brazil
Correspondence Address:
José G.M. Costa
Molecular Bioprospection Postgraduation Program, Laboratory of Natural Products Research, Regional University of Cariri, 63105 - 000, Crato, CE
Brazil
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0253-7613.77359
Objective : In this work, we report the antibacterial and modulatory activity of Lantana montevidensis Briq.
Materials and Methods : The antibacterial activities of leaf (LELm) and root (RELm) extracts alone or in association with aminoglycosides were determined by a microdilution test. Multiresistant strains of Escherichia coli (Ec 27) and Staphylococcus aureus (Sa 358) were used.
Results : The results show the inhibitory activity of LELm against E. coli (minimal inhibitory concentration [MIC] 16 μg/mL) and S. aureus (MIC 128 μg/mL). The synergistic effect of the extracts and aminoglycosides was verified too. The maximum effects were obtained with RELm with gentamicin against E. coli with MIC reduction (312 to 2 μL).
Conclusion : The data from this study are indicative of the activity antibacterial of extracts of L. montevidensis and its potential in modifying the resistance of aminoglycosides.
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