| RESEARCH ARTICLE
|Year : 2011 | Volume
| Issue : 1 | Page : 27-30
Anticonvulsant and neurotoxicity profile of the rhizome of Smilax china Linn. in mice
A Vijayalakshmi, V Ravichandiran, J Anbu, Malarkodi Velraj, S Jayakumari
Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels University, Chennai - 117, Tamil Nadu, India
Objective : To study the anticonvulsant activity and neurotoxicity of ethanolic extract and ethyl acetate fraction of the rhizome of Smilax china (EESC and EAF, respectively) in mice.
Materials and Methods : The anticonvulsant activities of EESC and EAF were studied against maximal electroshock (MES) and pentylenetetrazole (PTZ)-induced seizures in mice and neurotoxicity was determined using rotarod test.
Results : The duration of hindleg extension in MES test was reduced significantly (P < 0.001) by EESC at a dose level of 400 mg/kg and EAF at both higher dose levels (200 and 400 mg/kg). In PTZ model, the seizure latency was prolonged by all the test groups.
Conclusion : The EESC and EAF may help to control petit mal and grand mal seizures.
Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels University, Chennai - 117, Tamil Nadu
Source of Support: None, Conflict of Interest: None
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