| SHORT COMMUNICATION |
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| Year : 2010 | Volume
: 42
| Issue : 6 | Page : 409-411 |
Screening of anti-inflammatory and antipyretic activity of Vitex leucoxylon Linn
Padmini Shukla1, P Shukla1, SB Mishra2, B Gopalakrishna3
1 Pranveer Singh Institute of Technology, Kanpur, India
2 Roorki College of Pharmacy, Roorki, Uttar Pradesh, India
3 R.R. College of Pharmacy, Chikbanawara, Bangalore, India
Correspondence Address:
P Shukla
Pranveer Singh Institute of Technology, Kanpur
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0253-7613.71891
Objective: This study was designed to evaluate the anti-inflammatory and antipyretic activity of ethyl acetate extract of Vitex leucoxylon Linn. in various animal experimental models.
Materials and Methods: Ethyl acetate extract of V. leucoxylon Linn. evaluated for anti-inflammatory activity in carrageenan, mediator-induced rat paw edema, and cotton pellet-induced granuloma model. The antipyretic activity was evaluated by yeast-induced pyrexia model.
Results: Single administration of the ethyl acetate extract of V. leucoxylon Linn. at dose of 500 mg/kg p.o. showed significant (P < 0.001) inhibition of rat paw edema. The ethyl acetate extract showed significant antipyretic activity in brewer yeast-induced pyrexia in rats throughout the observation period of 4 h.
Conclusion: This study shows that ethyl acetate extract of V. leucoxylon Linn. has significant anti-inflammatory and antipyretic activity.
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