| RESEARCH ARTICLE
|Year : 2010 | Volume
| Issue : 5 | Page : 273-276
Antipyretic and antibacterial activity of Chloranthus erectus (Buch.-Ham.) Verdcourt leaf extract: A popular folk medicine of Arunachal Pradesh
Hui Tag1, Nima D Namsa2, M Mandal3, P Kalita1, AK Das1, SC Mandal4
1 Pharmacognosy Research Laboratory, Department of Botany, Rajiv Gandhi University, Rono Hills, Itanagar - 7911 13, Arunachal Pradesh, India
2 Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore - 560 012, India
3 Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur - 784 028, Assam, India
4 Division of Pharmacognosy, Department of Pharmaceutical Technology, Jadavpur University, Jadavpur, Kolkata - 700032, India
Objective : The main objective of this work was to study the antipyretic and antibacterial activity of C. erectus (Buch.-Ham.) Verdcourt leaf extract in an experimental albino rat model.
Materials and Methods : The methanol extract of C. erectus leaf (MECEL) was evaluated for its antipyretic potential on normal body temperature and Brewer's yeast-induced pyrexia in albino rat's model. While the antibacterial activity of MECEL against five Gram (-) and three Gram (+) bacterial strains and antimycotic activity was investigated against four fungi using agar disk diffusion and microdilution methods.
Result : Yeast suspension (10 mL/kg b.w.) elevated rectal temperature after 19 h of subcutaneous injection. Oral administration of MECEL at 100 and 200 mg/kg b.w. showed significant reduction of normal rectal body temperature and yeast-provoked elevated temperature (38.8 ± 0.2 and 37.6 ± 0.4, respectively, at 2-3 h) in a dose-dependent manner, and the effect was comparable to that of the standard antipyretic drug-paracetamol (150 mg/kg b.w.). MECEL at 2 mg/disk showed broad spectrum of growth inhibition activity against both groups of bacteria. However, MECEL was not effective against the yeast strains tested in this study.
Conclusion : This study revealed that the methanol extract of C. erectus exhibited significant antipyretic activity in the tested models and antibacterial activity as well, and may provide the scientific rationale for its popular use as antipyretic agent in Khamptis's folk medicines.
Nima D Namsa
Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore - 560 012
Source of Support: None, Conflict of Interest: None
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