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 RESEARCH ARTICLE
Year : 2010  |  Volume : 42  |  Issue : 4  |  Page : 234-237

Evaluation of Cassia occidentalis for in vitro cytotoxicity against human cancer cell lines and antibacterial activity


School of Biotechnology, University of Jammu, Jammu, India

Correspondence Address:
Madhulika Bhagat
School of Biotechnology, University of Jammu, Jammu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.68428

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Objective : To evaluate the in vitro cytotoxicity and antibacterial properties of Cassia occidentalis (whole plant) via alcoholic, hydro-alcoholic, and aqueous extracts against eight human cancer cell lines from six different tissues and four bacterial strains. Material and Methods : In vitro cytotoxicity against the human cancer cells, cultured for 48h in presence of different concentrations C. occidentalis extracts and percentage of cell viability, was evaluated using the sulforhodamine-B (SRB) assay. The antibacterial activity was performed using the standard protocol against bacterial strains. Results : It was observed that aqueous extract of C. occidentalis (whole plant) had more potential than hydro-alcoholic and alcoholic extracts against HCT-15, SW-620, PC-3, MCF-7, SiHa, and OVCAR-5 human cancer cell lines at 100, 30, and 10 μg/ml in a dose-dependent manner. The hydro-alcoholic extract showed potential against Bacillus subtillis. Conclusion : The plant can be explored for the possible development of lead molecules for drug discovery.






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