| EDUCATIONAL FORUM |
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| Year : 2010 | Volume
: 42
| Issue : 3 | Page : 129-134 |
Animal models and biomarkers of neuropathy in diabetic rodents
AS Shaikh, RS Somani
Department of Pharmacology, Sinhgad College of Pharmacy, Pune - 411 041, India
Correspondence Address:
R S Somani
Department of Pharmacology, Sinhgad College of Pharmacy, Pune - 411 041
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0253-7613.66833
Diabetic neuropathy (DN) is a multifactor complication of diabetes. It is a late finding in type 1 diabetes, but can be an early finding in type 2 diabetes. The cause of DN is still unclear and, like other complications of diabetes, it may be the result of various pathological conditions. Animal models and biomarkers of DN have been extensively used in neuropathic research. The most useful model of DN should exhibit the key feature present in human pathology. Diabetic rodents show behavioral, functional, structural and molecular biomarkers and they are widely used as models to investigate the etiology of DN as well as to screen the efficacy of the potential therapeutic interventions. We have reviewed the different animal models and biomarkers of neuropathy in diabetic rodents of either type 1 or type 2 diabetes.
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