| RESEARCH ARTICLE |
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| Year : 2010 | Volume
: 42
| Issue : 2 | Page : 82-86 |
The antiepileptic effect of Centella asiatica on the activities of Na + /K + , Mg 2+ and Ca 2+ -ATPases in rat brain during pentylenetetrazol-induced epilepsy
G Visweswari1, K Siva Prasad1, V Lokanatha2, W Rajendra1
1 Department of Zoology, Division of Molecular Biology, Sri Venkateswara University, Tirupati, India
2 Department of Biotechnology, Dravidian University, Kuppam, Andhra Pradesh, India
Correspondence Address:
W Rajendra
Department of Zoology, Division of Molecular Biology, Sri Venkateswara University, Tirupati
India
 Source of Support: University Grants Commission, Conflict of Interest: None  | Check |
DOI: 10.4103/0253-7613.64504
Background: To study the anticonvulsant effect of different extracts of Centella asiatica (CA) in male albino rats with reference to Na + /K + , Mg 2+ and Ca 2+ -ATPase activities.
Materials and Methods: Male Wistar rats (150±25 g b.w.) were divided into seven groups of six each i.e. (a) control rats treated with saline, (b) pentylenetetrazol (PTZ)-induced epileptic group (60 mg/kg, i.p.), (c) epileptic group pretreated with n-hexane extract (n-HE), (d) epileptic group pretreated with chloroform extract (CE), (e) epileptic group pretreated with ethyl acetate extract (EAE), (f) epileptic group pretreated with n-butanol extract (n-BE), and (g) epileptic group pretreated with aqueous extract (AE).
Results: The activities of three ATPases were decreased in different regions of brain during PTZ-induced epilepsy and were increased in epileptic rats pretreated with different extracts of CA except AE.
Conclusion: The extracts of C. asiatica, except AE, possess anticonvulsant and neuroprotective activity and thus can be used for effective management in treatment of epileptic seizures.
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