| RESEARCH ARTICLE
|Year : 2010 | Volume
| Issue : 1 | Page : 17-20
Analgesic and anti-inflammatory activity of amifostine, DRDE-07, and their analogs, in mice
Yangchen Doma Bhutia, Rajagopalan Vijayaraghavan, Uma Pathak
Defence Research and Development Establishment, Gwalior, India
Objectives : To find out the analgesic and anti-inflammatory activity, if any, of Amifostine [S-2(3 amino propyl amino) ethyl phosphorothioate], DRDE-07 [S-2(3 amino ethyl amino) ethyl phenyl sulphide] and their analogs DRDE-30 and DRDE-35, the probable prophylactic agent for sulphur mustard (SM).
Materials and Methods : In order to find out the analgesic activities of the compounds two methods were employed, namely, acetic acid-induced writhing test and formalin-induced paw licking. The persistent pain model of formalin-induced hind paw licking was carried out to test the effect of the compounds on neurogenic pain or early phase (0 to 5 minutes) and on the peripheral pain or the late phase (15 to 30 minutes). To test the effect of the compound in acute inflammation, carrageenan-induced hind paw edema was carried out. This model of inflammation involves a variety of mediators of inflammation.
Results : DRDE-07 (81.7%) and DRDE-30 (79.4%) showed significant reduction in the acetic acid-induced writhing test. DRDE-07 (93.1%), DRDE-30 (82%), and DRDE-35 (61.3%) showed significant reduction in the second or late phase of formalin-induced paw licking. All the analogs (more than 60%) including amifostine (43.9%) showed significant reduction of paw edema in the carrageenan-induced paw edema in mice.
Conclusion : The analgesic and anti-inflammatory activity of the antidotes were comparable with aspirin.
Yangchen Doma Bhutia
Defence Research and Development Establishment, Gwalior
Source of Support: None, Conflict of Interest: None
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