| RESEARCH ARTICLE
|Year : 2009 | Volume
| Issue : 2 | Page : 75-79
Screening of Bauhinia purpurea Linn. for analgesic and anti-inflammatory activities
CS Shreedhara1, VP Vaidya2, HM Vagdevi2, KP Latha2, KS Muralikrishna3, AM Krupanidhi2
1 Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal - 576 104, India
2 Department of Chemistry, Jnana Sahyadri, Shankaraghatta - 577 451, India
3 Bapuji Pharmacy College, Davanagere - 577 004, India
Objectives: Ethanol extract of the stem of Bauhinia purpurea Linn. was subjected to analgesic and anti-inflammatory activities in animal models.
Materials and Methods: Albino Wistar rats and mice were the experimental animals respectively. Different CNS depressant paradigms like analgesic activity (determined by Eddy's hot plate method and acetic acid writhing method) and anti-inflammatory activity determined by carrageenan induced paw edema using plethysmometer in albino rats) were carried out, following the intra-peritoneal administration of ethanol extract of Bauhinia purpurea Linn. (BP) at the dose level of 50mg/kg and 100mg/kg.
Results: The analgesic and anti-inflammatory activities of ethanol extracts of BP were significant (P < 0.001). The maximum analgesic effect was observed at 120 min at the dose of 100mg/kg (i.p.) and was comparable to that of standard analgin (150mg/kg) and the percentage of edema inhibition effect was 46.4% and 77% for 50mg/kg and 100mg/kg (i.p) respectively. Anti-inflammatory activity was compared with standard Diclofenac sodium (5mg/kg).
Conclusion: Ethanol extract of Bauhinia purpurea has shown significant analgesic and anti-inflammatory activities at the dose of 100 mg/kg and was comparable with corresponding standard drugs. The activity was attributed to the presence of phytoconstituents in the tested extract.
C S Shreedhara
Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal - 576 104
Source of Support: None, Conflict of Interest: None
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