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Year : 2009  |  Volume : 41  |  Issue : 2  |  Page : 72-74

Is cytochrome modulation the new frontier for decreasing the risk of cataract?

Department of Pharmacology, Anand Pharmacy College, Opp Town Hall, Anand - 388 001, Gujarat, India

Correspondence Address:
Kavitha S Nair
Department of Pharmacology, Anand Pharmacy College, Opp Town Hall, Anand - 388 001, Gujarat
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0253-7613.51344

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Aim: The present study was designed to study the effect of cytochrome P450 (CYP) modulators on the occurrence of cataract using male Sprague-Dawley rats weighing 40:50 gm. Materials and Methods: Macroscopical examination of the lens isolated from rats pretreated with diltiazem (30 mg/kg; once daily; PO) showed delayed occurrence of cataract while pioglitazone (3.8 mg/kg; once daily; PO) pretreatment demonstrated an early cataract. Results and Conclusion: A delayed occurrence of cataract with diltiazem (CYP inhibitor) and an early onset of cataract with pioglitazone (CYP inducer) indicate that a cytochrome P450 mediated pathway may affect the initiation of cataract but not the maturation pattern.


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