| RESEARCH ARTICLE
|Year : 2008 | Volume
| Issue : 6 | Page : 248-250
The effect of sodium valproate on the biochemical parameters of reproductive function in male albino Wistar rats
P Vijay1, R Yeshwanth2, KL Bairy3
1 Department of Anatomy, Maleka Manipal Medical College, Manipal, India
2 Department of Pharmacology, Maleka Manipal Medical College, Manipal, India
3 Department of Pharmacology, Kasturba Medical College, Manipal, India
Objective: To assess the effects of sodium valproate on intratesticular testosterone and lactic dehydrogenase level in rats.
Methods: Male Wistar rats (12 weeks old) were treated with sodium valproate and sacrificed at the end of the 2 nd , 4 th , 5 th , 7 th , 10 th and 15 th week, after the last exposure to sodium valproate. The testes were removed, weighed and processed for biochemical analysis.
Results: The intratesticular testosterone level was significantly (P<0.001) reduced in 200 mg/kg and 400 mg/kg treated rats. The intratesticular lactate dehydrogenase (LDH) level was significantly (P<0.001) increased by valproate in a time dependent manner.
Conclusion: Valproate causes reversible change in intratesticular testosterone and LDH level.
K L Bairy
Department of Pharmacology, Kasturba Medical College, Manipal
Source of Support: None, Conflict of Interest: None
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