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Year : 2008  |  Volume : 40  |  Issue : 6  |  Page : 248-250

The effect of sodium valproate on the biochemical parameters of reproductive function in male albino Wistar rats

1 Department of Anatomy, Maleka Manipal Medical College, Manipal, India
2 Department of Pharmacology, Maleka Manipal Medical College, Manipal, India
3 Department of Pharmacology, Kasturba Medical College, Manipal, India

Correspondence Address:
K L Bairy
Department of Pharmacology, Kasturba Medical College, Manipal
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0253-7613.45149

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Objective: To assess the effects of sodium valproate on intratesticular testosterone and lactic dehydrogenase level in rats. Methods: Male Wistar rats (12 weeks old) were treated with sodium valproate and sacrificed at the end of the 2 nd , 4 th , 5 th , 7 th , 10 th and 15 th week, after the last exposure to sodium valproate. The testes were removed, weighed and processed for biochemical analysis. Results: The intratesticular testosterone level was significantly (P<0.001) reduced in 200 mg/kg and 400 mg/kg treated rats. The intratesticular lactate dehydrogenase (LDH) level was significantly (P<0.001) increased by valproate in a time dependent manner. Conclusion: Valproate causes reversible change in intratesticular testosterone and LDH level.


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