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 RESEARCH ARTICLE
Year : 2008  |  Volume : 40  |  Issue : 3  |  Page : 107-110

Immunomodulatory effect of Tinospora cordifolia extract in human immuno-deficiency virus positive patients


1 Department of Pharmacology, Government Medical College, Nagpur - 440 003, India
2 Department of Preventive and Social Medicine, Government Medical College, Nagpur - 440 003, India
3 Department of Skin and Venereal Diseases, Government Medical College, Nagpur - 440 003, India
4 Department of Rasa Shastra, Government Ayurvedic College, Nagpur- 440009, India

Correspondence Address:
V R Thawani
Department of Pharmacology, Government Medical College, Nagpur - 440 003
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.42302

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Objectives: To assess the safety and efficacy of TCE in human immuno-deficiency virus positive patients. Materials and Methods: Efficacy of Tinospora cordifolia extract (TCE) in HIV positive patients was assessed in randomized double blind placebo controlled trial. 68 HIV positive participants were randomly assigned to two groups to receive either TCE or placebo for six months. After clinical examination TLC, DLC, ESR, platelet count, hemoglobin and CD4 count were done. The hematological investigations were repeated at bimonthly intervals and CD4 count was repeated at the end of the study. Patients were clinically reviewed at monthly intervals for compliance, refill and ADR monitoring. The drugs were decoded at the end of the trial. Results: TCE treatment caused significant reduction in eosinophil count and hemoglobin percentage. 60% patients receiving TCE and 20% on placebo reported decrease in the incidence of various symptoms associated with disease. Some of the common complaints reported by patients on TCE were anorexia, nausea, vomiting and weakness. Conclusion: Tinospora cordifolia extract, a plant derived immunostimulant, significantly affected the symptoms of HIV. This was validated by clinical evaluation. However not all of the objective parameters studied by us, back this up. Tinospora cordifolia could be used as an adjunct to HIV/AIDS management.






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