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 RESEARCH ARTICLE
Year : 2007  |  Volume : 39  |  Issue : 6  |  Page : 281-283

Free radical scavenging activity of gossypin and nevadensin: An in-vitro evaluation


1 Pharmacognosy and Phytochemistry Division, College of Pharmaceutical Sciences, Andhra University, Visakhapatnam - 530 003, Andhra Pradesh, India
2 Department of Pharmacology, Hanagal Shri Kumareshwar College of Pharmacy, BVVS Campus, Bagalkot - 587 101, Karnataka, India
3 Center of Biotechnology, Institute of Science and Technology, JNTU, Hyderabad - 500 072, Andhra Pradesh, India

Correspondence Address:
S Ganapaty
Pharmacognosy and Phytochemistry Division, College of Pharmaceutical Sciences, Andhra University, Visakhapatnam - 530 003, Andhra Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.39147

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Objectives: The antioxidant potential of gossypin and nevadensin, two flavonoid compounds, were evaluated by in vitro methods. Materials and Methods: Gossypin, nevadensin, and the reference standard, butylated hydroxyl toluene (BHT), were evaluated for DPPH (1, 1-diphenyl-2-picrylhydrazyl), nitric oxide, superoxide, and hydroxyl radical scavenging activity. Results: Gossypin and BHT showed the potential for significant DPPH radical inhibition of up to 88.52 and 91.45% at 100 g/ml concentration. With a 100 g/ml concentration of gossypin, the in vitro nitric oxide, superoxide, and hydroxyl radical scavenging activity was found to be 74.00, 74.22, and 67.15%, respectively; and with 100 g/ml of BHT the corresponding values were 82.24, 81.76, and 73.03% of inhibition, respectively. Conclusion: The study results showed that gossypin has significant antioxidant activity.






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