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 RESEARCH PAPER
Year : 2007  |  Volume : 39  |  Issue : 4  |  Page : 184-186

Antitumor activity of biflavonoids from Ouratea and Luxemburgia on human cancer cell lines


1 Departamento de Química, Instituto de Ciências Exatas, Universidade Federal Rural do Rio de Janeiro, Seropédica, RJ, Brazil
2 Laboratório de Marcadores de Estresse Celular, Centro de Pesquisas em Ciências Médicas, Universidade Luterana do Brasil, Canoas-RS; Programa de Pós-Graduação em Diagnóstico Genético e Molecular, Universidade Luterana do Brasil, Canoas-RS, Brazil

Correspondence Address:
Mario Geraldo de Carvalho
Departamento de Química, Instituto de Ciências Exatas, Universidade Federal Rural do Rio de Janeiro, Seropédica, RJ
Brazil
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.36536

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The biflavones 7,7"-dimethyllanaraflavone (1), agathisflavone (2), and 7"-methylagathisflavone (3) isolated from the leaves of Ouratea hexasperma and luxenchalcone (4) isolated from the leaves and branches of Luxemburgia octandra, as well as a mixture of 7,7"-dimethyllanaraflavone and 7"-methylagathisflavone, were assayed against HT-29 colon adenocarcinoma, NCl-H460 non-small cell lung carcinoma, MCF-7 breast cancer cell, OVCAR-3 ovarian adenocarcinoma cells, and RXF-393 renal cell carcinoma. The results show significant activities, particularly for 7,7"-dimethyllanaraflavone (IC 50 0.77 ± 0.08, 2.42 ± 0.22, and 2.59 ± 0.32 mg/ml for NCl-H460, MCF-7, and OVCAR-3, respectively), and for 7"-methylagathisflavone (IC 50 values of 4 mg/ml). Luxenchalcone revealed significant cytotoxicity on the five cell lines tested.






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