| EDUCATIONAL FORUM
|Year : 2007 | Volume
| Issue : 3 | Page : 129-139
Herb-drug interactions: A review and study based on assessment of clinical case reports in literature
KJ Gohil1, JA Patel2
1 Department of Pharmacology, Maliba Pharmacy College, Gopal Vidyanagar, Tarsadi, Bardoli, Surat, India
2 Department of Pharmacology, Institute of Pharmacy, Nirma University of Science and Technology, Ahmedabad, India
Objective : To conduct a systematic review of literature on interactions between conventional drugs and various herbs.
Materials and Methods : We carried out a literature survey to assess published herb-drug interaction information in clinical case reports and case series to check the report reliabilities.
Results : From 133 cases of suspected interactions, 67% cases were classified as possible interactions, 27% cases were unable to be evaluated and only 6% of the cases were well-documented. St. John's wort was the most common herb involved (37 cases) in drug interactions. Warfarin was the most common drug (34 cases) interacting with various herbs.
Conclusion : Herb-drug interactions are a stark reality today. Hence, proper reporting of cases, careful vigilance, evidence-based appraisal and constantly updated reviews of such herb-drug interactions are very important to promote systematic research.
J A Patel
Department of Pharmacology, Institute of Pharmacy, Nirma University of Science and Technology, Ahmedabad
Source of Support: None, Conflict of Interest: None
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