IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 1727 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded1028    
    Comments [Add]    
    Cited by others 27    

Recommend this journal


Year : 2006  |  Volume : 38  |  Issue : 4  |  Page : 254-259

Pharmacological evaluation of the extracts of Sphaeranthus indicus flowers on anxiolytic activity in mice

Department of Pharmacology, Bharati Vidyapeeth, Deemed University, Poona College of Pharmacy, Erandwane, Pune - 411 038, India

Correspondence Address:
S L Bodhankar
Department of Pharmacology, Bharati Vidyapeeth, Deemed University, Poona College of Pharmacy, Erandwane, Pune - 411 038
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0253-7613.27021

Rights and Permissions

Objective: The objective of the study was to investigate the anxiolytic activity of petroleum ether, alcohol and water extracts, obtained from the flowers of Sphaeranthus indicus Linn, in mice. Materials and Methods: Elevated plus maze (EPM), open field test (OFT) and foot-shock induced aggression (FSIA) were the screening tests used to assess the anxiolytic activity of the extracts on mice. Diazepam (1 mg/kg) served as the standard anxiolytic agent. Results: The animals receiving extracts or diazepam (1 mg/kg) showed an increase in the time spent, percent entries and total entries in the open arm of the EPM; increased ambulation, activity at centre and total locomotion in the OFT; and decreased fighting bouts in the FSIA, suggesting anxiolytic activity. Petroleum ether extract (10 mg/kg), alcoholic extract (10 mg/kg) and water extract (30 mg/kg) resulted in prominent activity in the mice. Petroleum ether extract (10 mg/kg) resulted in more prominent anxiolytic activity in the EPM and OFT than ethanolic or water extracts, but was less than that produced by diazepam (1 mg/kg). Conclusion: Petroleum ether extract of S. indicus flowers produces prominent anxiolytic activity in mice.


Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer | Privacy Notice
Online since 20th July '04
Published by Wolters Kluwer - Medknow