| EDUCATIONAL FORUM |
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| Year : 2006 | Volume
: 38
| Issue : 4 | Page : 238-242 |
Drugs and non-alcoholic steatohepatitis
SK Das, DM Vasudevan
Department of Biochemistry, Amrita Institute of Medical Sciences, Elamakkara P.O., Cochin-682 026, Kerala, India
Correspondence Address:
S K Das
Department of Biochemistry, Amrita Institute of Medical Sciences, Elamakkara P.O., Cochin-682 026, Kerala
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0253-7613.27019
Health complications associated with obesity include diabetes, hypertension, hyperlipidemia, cardiovascular disease, and associated co-morbidities including non-alcoholic steatohepatitis (NASH). Additionally, NASH has been associated with several drugs. Though steatohepatitis is a rare form of drug induced liver disease, it has generated great interest in the recent past. Oral hypoglycemic agents, lipid lowering agents, antihypertensives, and antiobesity medication underlie a significant proportion of well-recognized hepatotoxicity. While some medications have predictable toxicity, many more are associated with idiosyncratic reactions. The toxic mechanism appears to involve mitochondrial injury, impaired β -oxidation, generation of reactive oxygen species and ATP depletion. If a drug is suspected, it is probably prudent to stop this medication.
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