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 EDUCATIONAL FORUM
Year : 2006  |  Volume : 38  |  Issue : 4  |  Page : 238-242

Drugs and non-alcoholic steatohepatitis


Department of Biochemistry, Amrita Institute of Medical Sciences, Elamakkara P.O., Cochin-682 026, Kerala, India

Correspondence Address:
S K Das
Department of Biochemistry, Amrita Institute of Medical Sciences, Elamakkara P.O., Cochin-682 026, Kerala
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.27019

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Health complications associated with obesity include diabetes, hypertension, hyperlipidemia, cardiovascular disease, and associated co-morbidities including non-alcoholic steatohepatitis (NASH). Additionally, NASH has been associated with several drugs. Though steatohepatitis is a rare form of drug induced liver disease, it has generated great interest in the recent past. Oral hypoglycemic agents, lipid lowering agents, antihypertensives, and antiobesity medication underlie a significant proportion of well-recognized hepatotoxicity. While some medications have predictable toxicity, many more are associated with idiosyncratic reactions. The toxic mechanism appears to involve mitochondrial injury, impaired β -oxidation, generation of reactive oxygen species and ATP depletion. If a drug is suspected, it is probably prudent to stop this medication.






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