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Year : 2006  |  Volume : 38  |  Issue : 4  |  Page : 231-237

Glucagon like peptide-1: A new therapeutic target for diabetes mellitus

1 Shri Sarvajanik Pharmacy College, Near Arvind Baug, Mehsana-384001, Gujarat, India
2 L.M. College of Pharmacy, Navrangpura, Ahmedabad-380009, Gujarat, India

Correspondence Address:
S K Patel
Shri Sarvajanik Pharmacy College, Near Arvind Baug, Mehsana-384001, Gujarat
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0253-7613.27018

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Glucagon-like peptide-1 (GLP-1) is an endogenous peptide secreted from the gut in response to the presence of food. GLP-1 and its longer acting analog exendin-4 have multiple synergistic effects on glucose dependent, insulin secretion pathways of the pancreatic β-cell and on plasticity in neuronal cells. Recently the development of these peptides as a novel therapeutic strategy for non-insulin-dependent (type 2) diabetes mellitus and associated neuropathy has been the focus of much interest. Here we describe the biological actions of GLP-1 and its related analogs.


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