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| RESEARCH PAPER |
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| Year : 2006 | Volume
: 38
| Issue : 1 | Page : 49-53 |
Antihyperglycemic activity of aqueous extract of leaves of Cocculus hirsutus (L.) Diels in alloxan-induced diabetic mice.
S Badole1, N Patel1, S Bodhankar1, B Jain1, S Bhardwaj2
1 Department of Pharmacology, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane,Pune-411 038, India
2 Clinical Research, Serum Institute of India, Hadpsar, Pune-411 007, India
Correspondence Address:
S Bodhankar
Department of Pharmacology, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane,Pune-411 038
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0253-7613.19853
Objective: To evaluate the antihyperglycemic activity of aqueous extract of leaves of Cocculus hirsutus (L.) Diels in alloxan-induced diabetic mice. Materials and Methods: Alloxan-induced (70 mg/kg, i.v.) diabetic mice were given aqueous leaf extract (250, 500, and 1000 mg/kg, p.o., n= 6) of C. hirsutus or vehicle (distilled water, 10 ml/kg, p.o.) or standard drug glyburide (10 mg/kg, p.o.) for 28 days. Blood samples were withdrawn by retro-orbital puncture and were analyzed for serum glucose on 0th, 7th, 14th, 21st, and 28th days by glucose oxidase/peroxidase method. In oral glucose tolerance test, glucose (2.5 g/kg, p.o.) was administered to nondiabetic control, glyburide (10 mg/kg, p.o.), and aqueous extract of C. hirsutus (1000 mg/kg, p.o.) treated mice. The serum glucose level was analyzed at 0, 30, 60, and 120 min after drug administration. Results: The aqueous leaf extract of C. hirsutus (250, 500, and 1000 mg/kg, p.o.) showed significant ( P< 0.01) reduction of serum glucose level in alloxan-induced diabetic mice at 28th day. In oral glucose tolerance test, aqueous extract of C. hirsutus increased the glucose tolerance. Conclusion: It is concluded that C. hirsutus has significant antihyperglycemic activity as it lowers serum glucose level in diabetic mice and significantly increases glucose tolerance.
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