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 RESEARCH PAPER
Year : 2005  |  Volume : 37  |  Issue : 6  |  Page : 376-380

Hypolipidemic and antioxidant activities of Asparagus racemosus in hypercholesteremic rats


Department of Biosciences, Sardar Patel University, Vallabh Vidyanagar - 388 120. Gujarat, India

Correspondence Address:
A V R.L. Narasimhacharya
Department of Biosciences, Sardar Patel University, Vallabh Vidyanagar - 388 120. Gujarat
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.19074

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OBJECTIVE: To study the efficacy of Asparagus racemosus in reducing the cholesterol levels and as an antioxidant in hypercholesteremic rats. MATERIALS AND METHODS: Hypercholesteremia was induced in normal rats by including 0.75 g% cholesterol and 1.5 g% bile salt in normal diet and were used for the experiments. Dried root powder of Asparagus racemosus was administered as feed supplement at 5 g% and 10 gm% dose levels to the hypercholesteremic rats. Plasma and liver lipid profiles, hepatic HMG-CoA reductase, bile acid, malondialdehyde, ascorbic acid, catalase and SOD, fecal bile acid, cholesterol and neutral sterols were estimated using standard methods. RESULTS: Feed supplementation with 5 g% and 10 g% Asparagus racemosus resulted in a significant decline in plasma and hepatic lipid profiles. The feed supplementation increased the HMG-CoA reductase activity and bile acid production in both groups (5 and 10 g% supplemented groups) with concomitant increase in fecal bile acid and fecal cholesterol excretion. The activities of catalase, SOD and ascorbic acid content increased significantly in both the experimental groups (5 and 10 g% supplemented groups). On the other hand, the concentration of malondialdehyde in these groups (5 and 10 g% supplemented groups) decreased significantly, indicating decreased lipid peroxidation. CONCLUSION: The present study demonstrates that addition of Asparagus racemosus root powder at 5 g% and 10 g% level as feed supplement reduces the plasma and hepatic lipid (cholesterol) levels and also decreases lipid peroxidation.






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