IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 21501 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 » Next article
 » Previous article 
 » Table of Contents
Resource Links
 »  Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »  Article in PDF (108 KB)
 »  Citation Manager
 »  Access Statistics
 »  Reader Comments
 »  Email Alert *
 »  Add to My List *
* Registration required (free)

In This Article
 »  Acknowledgments
 »  References
 »  Article Figures

 Article Access Statistics
    PDF Downloaded263    
    Comments [Add]    
    Cited by others 5    

Recommend this journal


Year : 2005  |  Volume : 37  |  Issue : 4  |  Page : 259-260

Influence of flavonoids isolated from Satureja hortensis L. on hypercholesterolemic rabbits

Iv. Javakhishvili State University, Biological Faculty, Department of Biophysics, Tbilisi, Georgia

Correspondence Address:
G Davitaia
Iv. Javakhishvili State University, Biological Faculty, Department of Biophysics, Tbilisi
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0253-7613.16577

Rights and Permissions

How to cite this article:
Mchedlishvili D, Kuchukashvili Z, Tabatadze T, Davitaia G. Influence of flavonoids isolated from Satureja hortensis L. on hypercholesterolemic rabbits. Indian J Pharmacol 2005;37:259-60

How to cite this URL:
Mchedlishvili D, Kuchukashvili Z, Tabatadze T, Davitaia G. Influence of flavonoids isolated from Satureja hortensis L. on hypercholesterolemic rabbits. Indian J Pharmacol [serial online] 2005 [cited 2023 Sep 23];37:259-60. Available from: https://www.ijp-online.com/text.asp?2005/37/4/259/16577

Satureja hortensis L. (summer savory) is an annual herb with oval leaves and pink flowers widely distributed in Georgia, and locally named as 'Qondari'. Leaves and flowers of this plant are frequently used as tea or additive in commercial spice mixtures for many foods to offer aroma and flavor. S. hortensis L. has also been used as a folk remedy to treat various diseases and disorders such as cramps, muscle pain, indigestion, diarrhea, and infections, due to its antispasmodic, antidiarrheal as well as antimicrobial properties. Hypertension and hyperlipidemia are often the two coexisting risk factors in coronary artery disease. It has been well established that hypercholesterolemia is associated with various pathological processes such as cardiovascular diseases, diabetes mellitus, atherosclerosis, and thromboembolic disorders.[1] The effect of flavonoids from S. hortensis L. on serum cholesterol of rabbits was investigated in the present study.

The experiments were carried out for 8 weeks in 20 male, albino, New Zealand rabbits weighing between 2.1 and 2.5 kg. Rabbits were housed individually in stainless steel cages in an air-conditioned room (23 ± 1 oC) under a 12 h light/dark cycle and were acclimated for 2 weeks. One hundred and 50 g of regular rabbit chow was provided to each rabbit every day for a fixed duration of time. Water was given ad libitum . Animals were randomly divided into four groups of five rabbits each. (1) The standard diet group (Control), (2) high cholesterol diet group (Chol)-cholesterol, dissolved in sunflower-seed oil, administered daily p.o. 0.3 g/kg B.W; (3) flavonoids group (F) flavonoids fraction, dissolved in distilled water, administered daily intramuscularly in a dose of 10 mg/kg of B.W. Flavonoids fraction was received from the air-dried plant material of S . hortensis L. by the method of Zaprometov.[2] (4) high cholesterol diet plus flavonoids group (Chol+F): 0.3 g/kg, cholesterol p.o. + 10 mg/kg, flavonoids fraction i.m. Blood was collected from marginal ear vein from each animal and after clotting, centrifuged at 1000 X g for 10 min at 4 °C to obtain serum. The serum cholesterol was estimated before starting (basal value) and at the end of 8 weeks of treatment by standard method using "Lachema" kits (Czech Republic).

The results are expressed as mean±SD. Inter-group comparisons among the 4 groups were determined by one-way ANOVA followed by Scheffe's 'F' test. All analyses were performed using the GraphPad Prism software version 4.01; P<0.05 was considered statistically significant.

Mean serum cholesterol values at basal and at the end of 8 weeks of all groups of rabbits are shown in [Figure - 1]. The difference in pre- and post-experiment serum cholesterol in control and F group was not statistically significant (P>0.05). There was a significant increase in the mean serum cholesterol levels at the end of 8 weeks in the Chol group of rabbits from 1.12 ± 0.14 to 12.53 ± 0.62 mmol/L (P<0.0001). The corresponding rise, which was also significant in the Chol+F group of rabbits, was from 1.07 ± 0.09 to 5.34 ± 0.28 mmol/L (P<0.001). However, when the mean post-experiment serum cholesterol levels of Chol and Chol+F groups of rabbits were compared, the Chol+F group showed a significantly lower value than the Chol group (P<0.001). Thus, fraction F had significantly prevented the diet-induced rise of serum cholesterol.

Administration of flavonoids isolated from S. hortensis L. along with cholesterol in rabbits has resulted in a significant attenuation of rise in serum cholesterol value after 8 weeks, when compared to the cholesterol alone group. This suggests the cholesterol-lowering effect of fraction F in a situation of rising serum cholesterol. Though the hypolipidemic properties of flavonoids are well known,[3] such an effect of flavonoids from S. hortensis L. has not yet been shown.

Further studies are necessary to elicit the mechanism of action as well as to confirm these findings.

 » Acknowledgments Top

This work was supported by INTAS grant 99-1768.

 » References Top

1.Pyorala K, Laakso M, Uusiputa M. Diabetes and atherosclerosis: An epidemiological view. Diabetes 1987;3:463-524.  Back to cited text no. 1    
2.Zaprometov MN. The basis of biochemistry of phenolic compounds. Moscow: Visshaja Shkola (in Russian); 1974.  Back to cited text no. 2    
3.Chan PT, Fong WP, Cheung YL, Huang Y, Ho WK, Chen ZY. Jasmine green tea epicatechins are hypolipidemic in hamsters fed a high fat diet. J Nutr 1999;129:1094-101.  Back to cited text no. 3  [PUBMED]  [FULLTEXT]


[Figure - 1]

This article has been cited by
1 A comprehensive review of summer savory (Satureja hortensis L.): promising ingredient for production of functional foods
Afaf Ejaz, Sadaf Waliat, Muhammad Sajid Arshad, Waseem Khalid, Muhammad Zubair Khalid, Hafiz Ansar Rasul Suleria, Marian-Ilie Luca, Costel Mironeasa, Ana Batariuc, Madalina Ungureanu-Iuga, Ionica Cotovanu, Silvia Mironeasa
Frontiers in Pharmacology. 2023; 14
[Pubmed] | [DOI]
2 Flavonoid Accumulation in an Aseptic Culture of Summer Savory (Satureja hortensis L.)
Darya A. Khlebnikova, Evgeniya M. Efanova, Nina A. Danilova, Yaroslava V. Shcherbakova, Irina Rivera Sidorova
Plants. 2022; 11(4): 533
[Pubmed] | [DOI]
3 Evaluation of Chemical Composition, Radical Scavenging and Antitumor Activities of Satureja hortensis L. Herb Extracts
Kristina Bimbiraite-Surviliene, Mantas Stankevicius, Simona Šuštauskaite, Agnieszka Gegotek, Audrius Maruška, Elzbieta Skrzydlewska, Zita Barsteigiene, Ieva Akuneca, Ona Ragažinskiene, Audronis Lukošius
Antioxidants. 2021; 10(1): 53
[Pubmed] | [DOI]
4 An Update on Pharmacology of Satureja Species; From Antioxidant, Antimicrobial, Antidiabetes and Anti-hyperlipidemic to Reproductive Stimulation
Saeideh Momtaz, Mohammad Abdollahi
International Journal of Pharmacology. 2010; 6(4): 346
[VIEW] | [DOI]
5 Relaxant effect of Satureja hortensis on guinea pig tracheal chains and its possible mechanism(s)
Boskabady, M.H., Aslani, M.R., Mansuri, F., Amery, S.
Daru. 2007; 15(4): 199-204


Print this article  Email this article


Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer | Privacy Notice
Online since 20th July '04
Published by Wolters Kluwer - Medknow