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 RESEARCH PAPER
Year : 2005  |  Volume : 37  |  Issue : 2  |  Page : 120-125

Investigations of Sapindus trifoliatus in dopaminergic and serotonergic systems: Putative antimigraine mechanisms


1 New Chemical Entity Research, Lupin Research Park, Village Nande, Taluk Mulshi, Pune-411 042 and Department of Pharmacology, Bharati Vidyapeeth, Poona College of Pharmacy, Pune-411 038, India
2 New Chemical Entity Research, Lupin Research Park, Village Nande, Taluk Mulshi, Pune-411 042, India
3 Department of Pharmacology, Bharati Vidyapeeth, Poona College of Pharmacy, Pune-411 038, India

Correspondence Address:
A Veeranjaneyulu
New Chemical Entity Research, Lupin Research Park, Village Nande, Taluk Mulshi, Pune-411 042
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.15114

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OBJECTIVE: To evaluate the potential dopaminergic and serotonergic receptor-mediated modulatory effect of the aqueous extract of Sapindus trifoliatus [(ST), (family: Sapindaceae)], a traditional phytomedicine used in the treatment of hemicrania (migraine), using animal models and receptor assays. MATERIALS AND METHODS: ST (at 20 and 100 mg/kg, i.p. doses) was evaluated for its effect on apomorphine-induced climbing behavior, 5-hydroxytryptophan (l-5-HTP)-induced serotonin syndrome, and MK-801-induced hyperactivity in mice. The radioligand binding studies for various receptors and enzymes were carried out (outsourced) using standard procedures at 250 µg/ml concentration of ST. RESULTS: ST significantly inhibited the apomorphine-induced climbing behavior, the l-5-HTP-induced serotonin syndrome and MK-801-induced hyperactivity in mice. In the receptor radioligand binding studies, ST exhibited affinity towards dopamine D2, 5-HT2A receptors. CONCLUSION: The results of the behavioral studies in mice indicate that ST modulated D2 and 5-HT2A receptor-mediated paradigms. The radioligand binding studies supported these observations, suggesting the possible involvement of dopaminergic and serotonergic mechanisms in the antimigraine activity of ST.






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