IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 2265 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed8240    
    Printed271    
    Emailed7    
    PDF Downloaded368    
    Comments [Add]    
    Cited by others 6    

Recommend this journal

 

 RESEARCH PAPER
Year : 2005  |  Volume : 37  |  Issue : 2  |  Page : 111-115

Relaxant effect of Cuminum cyminum on guinea pig tracheal chains and its possible mechanism(s)


Deptartment of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad, Iran

Correspondence Address:
M H Boskabady
Deptartment of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad
Iran
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.15111

Rights and Permissions

OBJECTIVE: To examine the relaxant effects of the macerated and aqueous extracts of Cuminum cyminum on the tracheal chains of guinea pig. MATERIALS AND METHODS: The relaxant effects of cumulative concentrations of macerated and aqueous extracts (0.25, 0.5, 0.75 and 1.0 g%) in comparison with saline and theophylline (0.25, 0.5, 0.75, and 1.0 mM) were examined on pre-contracted tracheal chains of guinea pigs under different conditions. RESULTS: In Group 1 experiments (contracted by KCl) only the last two concentrations of theophylline and the highest concentration of macerated extract showed significant relaxant effect compared to that of saline (P<0.001 and P<0.05 for theophylline and macerated extract respectively). The effects of the last two concentrations of theophylline in this group were significantly greater than those of the macerated and aqueous extracts (P<0.001). However, in Group 2 experiments (contracted by methacholine) both the extracts and theophylline showed concentration-dependent relaxant effect compared to that of saline (P<0.05 to P<0.001). The effects of the two last concentrations of both extracts were significantly lower than those of theophylline in Group 2 experiments (P<0.05 to P<0.001). In Group 3 (non-incubated, contracted by methacholine) the extracts of Cuminum cyminum did not show any relaxant effect of tracheal chains. The relaxant effects of macerated and aqueous extracts in Groups 1 and 3 were significantly lower than those of Group 2 (P<0.05 to P<0.001). However, the effects of different concentrations of theophylline obtained in Group 1 and 2 were not significantly different. There was a significant correlation between the effects and concentrations of theophylline in Groups 1 and 2, macerated extract in Groups 2 and 3 and aqueous extract in Group 1 (P<0.05 to P<0.001). CONCLUSION: These results show a potent relaxant effect of Cuminum cyminum on guinea pig tracheal chains which may be due to a stimulatory effect of the plant on β-adrenoceptors and/or an inhibitory effect on histamine H1 receptors.






[FULL TEXT] [PDF]*


        
Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow