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Year : 2004  |  Volume : 36  |  Issue : 6  |  Page : 351-354

Calcium channel blockers reduce inflammatory edema in the rat: Involvement of the hypothalamus-pituitary-adrenal axis

1 Department of Physiology and Pharmacology, Faculty of Medicine, Kerman, Iran
2 Department of Physiology, Jahrom School of Medicine, Jahrom, Iran
3 Department of Biochemistry, Faculty of Medicine, Rafsanjan, Iran

Correspondence Address:
M Khaksari
Department of Physiology and Pharmacology, Faculty of Medicine, Kerman
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Source of Support: None, Conflict of Interest: None

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OBJECTIVE: To evaluate the role of calcium channel blockers and their mechanisms of action on acute inflammation of rat paw. MATERIAL AND METHODS: The study was conducted using carrageenan-induced rat paw inflammation model. Two different doses of nifedipine and verapamil (25 and 400 µg/kg, i.p.) were used. Edema was assessed by calculating the volume changes and by extravasation of Evans blue dye. RESULTS: Nifedipine reduced edema dose-dependently, whereas verapamil was effective only at low dose. Adrenalectomy prevented the effect of nifedipine and verapamil. With low dose of nifedipine 66% of antiinflammatory effect was observed. Pretreatment with -helical corticotropin releasing factor (CRF 9-41), a corticotropin-releasing hormone (CRH) receptor antagonist, had the same effect as that of adrenalectomy for either doses of verapamil, but only the effect of low-dose nifedipine was prevented completely. CONCLUSION: Our data suggest that verapamil and nifedipine exerts a potent antiinflammatory action possibly through pituitary adrenocortical activation.


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