| RESEARCH PAPER
|Year : 2004 | Volume
| Issue : 6 | Page : 348-350
Possible anorectic effect of methanol extract of Benincasa hispida (Thunb). Cogn, fruit
A Kumar1, R Vimalavathini2
1 TIFAC CORE in Herbal Drugs, Department of Phytopharmacy and Phytomedicine, J.S.S. College of Pharmacy, Ootacamund - 643 001, India
2 Department of Pharmacology and Toxicology, C.L. Baid Metha College of Pharmacy, Chennai - 600 096, India
OBJECTIVE: To investigate the anorectic effect of the methanol extract of Benincasa hispida (MEBH) in Swiss albino mice.
MATERIAL AND METHODS: Fasted mice were administered with various doses of MEBH (0.2-1 g/kg, i.p.), and the food intake was measured hourly for a period of 7 h. In another experiment, the percentage of gastric emptying at 4th h was determined after the administration of MEBH (0.2-1 g/kg, i.p.) in different set of mice which had free access to preweighed food for either 1, 2 or 4 h.
RESULTS: MEBH significantly reduced the cumulative food intake over a 7 h period in a dose-dependent manner. The percentage reduction of cumulative food intake at 7th h for MEBH with 0.2, 0.6 and 1 g/kg was 27%, 38% and 54% respectively. The 4 h gastric emptying was not significantly influenced by MEBH when compared to control.
CONCLUSION: The present study reveals for the first time a possible anorectic activity of Benincasa hispida, most probably mediated through the CNS without affecting the gastric emptying. However, further studies are required to find its potential as an antiobesity agent.
TIFAC CORE in Herbal Drugs, Department of Phytopharmacy and Phytomedicine, J.S.S. College of Pharmacy, Ootacamund - 643 001
Source of Support: None, Conflict of Interest: None
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