| RESEARCH PAPER |
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| Year : 2004 | Volume
: 36
| Issue : 5 | Page : 284-287 |
Protective activity of Glycyrrhiza glabra Linn. on carbon tetrachloride-induced peroxidative damage
MG Rajesh, MS Latha
School of Biosciences, Mahatma Gandhi University, P. D. Hills, P. O., Kottayam - 686 560, India
Correspondence Address:
M S Latha
School of Biosciences, Mahatma Gandhi University, P. D. Hills, P. O., Kottayam - 686 560
India
 Source of Support: None, Conflict of Interest: None  | Check |
OBJECTIVE: To evaluate the potential efficacy of Glycyrrhiza glabra Linn. (Fabaceae) in protecting tissues from peroxidative damage in CCl4-intoxicated rats.
MATERIAL AND METHODS: Peroxidative hepatic damage in rats was studied by assessing parameters such as thiobarbituric acid reactive substances (TBARS), conjugated dienes (CD), superoxidedismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione peroxidase (GSH-Px) and glutathione (GSH) in liver and kidneys. The effect of co-administration of G. glabra on the above parameters and histopathological findings of the liver in experimental animals was studied.
RESULTS: The increased lipid peroxide formation in the tissues of CCl4-treated rats was significantly inhibited by G. glabra. The observed decreased antioxidant enzyme activities of SOD, CAT, GSH-Px, GST, and antioxidant concentration of glutathione were nearly normalized by G. glabra treatment. Carbon tetrachloride-induced damage produces alteration in the antioxidant status of the tissues, which is manifested by abnormal histopathology. G. glabra restored all these changes.
CONCLUSION: Glycyrrhiza glabra is a potential antioxidant and attenuates the hepatotoxic effect of CCl4.
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