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 RESEARCH PAPER
Year : 2004  |  Volume : 36  |  Issue : 3  |  Page : 148-150

Preliminary studies on antiinflammatory and analgesic activities of Spilanthes acmella in experimental animal models


Department of Pharmacology, Regional Institute of Medical Sciences, Lamphelpat, Imphal - 795 004, India

Correspondence Address:
A Chakraborty
Department of Pharmacology, Regional Institute of Medical Sciences, Lamphelpat, Imphal - 795 004
India
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Source of Support: None, Conflict of Interest: None


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OBJECTIVE: To evaluate the antiinflammatory and analgesic activities of the aqueous extract of Spilanthes acmella (SPA) in experimental animal models. MATERIAL AND METHODS: SPA was evaluated for antiinflammatory action by carrageenan-induced rat paw edema. The analgesic activity was tested by acetic acid-induced writhing response in albino mice and tail flick method in albino rats. RESULTS: The aqueous extract of SPA in doses of 100, 200 and 400 mg/kg showed 52.6, 54.4 and 56.1% inhibition of paw edema respectively at the end of three hours and the percentage of protection from writhing was 46.9, 51.0 and 65.6 respectively. In the tail flick model, the aqueous extract of SPA in the above doses increased the pain threshold significantly after 30 min, 1, 2 and 4 h of administration. SPA showed dose-dependent action in all the experimental models. CONCLUSION: The present study indicates that SPA has significant antiinflammatory and analgesic properties.






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