| SHORT COMMUNICATION
|Year : 2002 | Volume
| Issue : 4 | Page : 251-255
Anticonvulsant activity of roots and rhizomes of Glycyrrhiza glabra
D Ambawade Shirish, Kasture S Veena, B Kasture Sanjay
Objective: To study the anticonvulsant activity of ethanolic extract of Glycyrrhiza glabra in albino rats and mice.
Methods: The anticonvulsant activity of ethanolic extract of roots and rhizomes of Glycyrrhiza glabra (10, 30, 100 and 500 mg/kg, i.p.) in mice was assessed using maximum electroshock seizure (MES) test and pentylenetetrazol (PTZ) using albino mice. The lithium-pilocarpine model of status epilepticus was also used to assess the anticonvulsant activity in rats.
Results: The ethanolic extract of G. glabra did not reduce the duration of tonic hindleg extension in the MES test even in the dose of 500 mg/kg. However, the extract significantly and dose-dependently delayed the onset of clonic convulsions induced by pentylenetetrazol. The dose of 100 mg/kg afforded protection to all animals. The extract also protected rats against seizures induced by lithium-pilocarpine.
Conclusion: The ethanolic extract of G. glabra inhibits PTZ and lithium-pilocarpine-induced convulsions but not MES-induced
D Ambawade Shirish
Source of Support: None, Conflict of Interest: None