| SHORT COMMUNICATION
|Year : 2002 | Volume
| Issue : 3 | Page : 189-193
Interaction between H2-receptor blocker and neuromuscular blockers in vitro
CB Tripathi, JD Bhatt, UD Panchakshari, KG Hemavathi, OD Gulati
1. A series of 9-alkylamino-1, 2, 3, 4-tetrahydroacridines and analogues were synthesized and tested for local ansesthetic activity in rabbits and guinea pigs.
2. 9-n-Heptylamino-1, 2, 3, 4-tetrahydroacridines showed the maximum activity and were more potent than lignocaine.
3. The local anaesthetic activity seems to be partly influenced by the lipophilicity of the compounds.
C B Tripathi
Source of Support: None, Conflict of Interest: None