|Year : 2001 | Volume
| Issue : 6 | Page : 445-451
A method for evaluation of variables in drug interaction
Qing-Shan Zheng, Chang-Qing Gui, Rui-Yuan Sun
1. The biochemical and haematological effects of tolmetin (a pyrole acetic acid derivative), on blood sugar,' serum cholesterol, serum uric acid, blood count, coagulation time, plasma fibrinogen content and euglobin clot lysis time (ELT) were studied in albino rabbits
2. Tolmetin (10 mg/kg), (P.O.) produced marked and significant hypoglycaemic, hypocholesterolaemic and hypouricaemic effects which started after one hour with a peak effect at two hours without complete recovery even upto four hours.
3. It decreased coagulation time and platelet count but increased plasma fibrinogen level and ELT.
Source of Support: None, Conflict of Interest: None