| SHORT COMMUNICATION
|Year : 2000 | Volume
| Issue : 6 | Page : 369-371
Toxicological and pharmacological study of navbal rasayan-A metal based formulation
Chandra Dinesh, AK Mandal
Objectives: Toxicological and pharmacological studies of "Navbal Rasayan" a metal based Ayurvedic formulation used for the treatment of multiple sclerosis, have been carried out.
Methods: Acute and chronic toxicities studies were conducted in rats with oral graded doses (0.37 to 3.0 g/kg) of Navbal Rasayan (NR). In-vitro study was carried out on isolated guinea pig ileum obtained from control or animal pretreated with oral NR, 1.5 g/kg for 3 days. Dose responses with acetylcholine, histamine and 5-HT were obtained. The analgesic activity of oral NR 1.5 g/kg for 3 days was evaluated in albino mice against acetic acid induced writhings. The hypnotic activity was measured with pentobarbital after oral pretreatment with 1.5 and 3.0 g/kg NR for 3 days. The anti-convulsant activity was observed in rats against i.p. pentylenetetrazol induced seizures.
Results: Oral administration of graded doses of NR (upto 3.0 g/kg) did not produce any acute or chronic toxicities in rats. Oral pretreatment of guinea pigs with NR (1.5 g/kg for 3 days) increased 36.43 time the histamine dose while the agonistic effect of acetylcholine and 5-hydroxytryptamine was completely attenuated. Further, NR neither exhibited any analgesic, sedative effect or anticonvulsant effect in rodents.
Conclusion: Toxicological and pharmacological study with NR in animals does not show any toxic effect. However, decrease or attenuation of agonistic activities of histamine, acetylcholine and serotonin needs further exploration.
Source of Support: None, Conflict of Interest: None