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Year : 2000  |  Volume : 32  |  Issue : 5  |  Page : 324-326

Effect of fish oil on isoproterenol induced myocardial necrosis

Correspondence Address:
Padma V Vijaya

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Objective: To study the effect of fish oil treatment on isoproterenol induced myocardial necrosis in rats. Methods: Four groups of rats each comprising of 6 animals were selected for this study. Group I served as control and Group II animals were given isoproterenol hydrochloride (60 mg/kg, s.c.). Group III animals were orally administered fish oil for a period of 45 days. Group IV animals received both fish oil (45 days) and isoproterenol (at the end of the fish oil treatment). The transaminases (AST and ALT), lactate dehydrogenase (LDH) and creatine phosphokinase (CK), in both serum and heart tissue and serum uric acid levels were estimated. Results: Isoproterenol significantly increased the activities of CK, LDH and transaminases in serum with concomitant decrease of these enzymes in tissue. Fish oil pretreatment maintained these enzyme activities at near normal. Serum uric acid level was increased on isoproterenol administration. Pretreatment with fish oil registered near normal values. Conclusion: The study confirms the protective effect of fish oil on isoproterenol induced biochemical alterations in rats.


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