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Year : 2000  |  Volume : 32  |  Issue : 5  |  Page : 318-320

Role of nitric oxide in central regulation of humoral immune response in rats

Correspondence Address:
Roy Sunita

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Source of Support: None, Conflict of Interest: None

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Objective: To investigate the role of nitric oxide (NO) in central regulation of immune response in rats. Methods: The investigation was carried out using sheep red blood cells (SRBC)-immunized rats. The animals were administered NO modulators intracerebroventricularly ( icv), both prior to, and following immunization. Blood collected postimmunization was analyzed for humoral immune response by haemagglutination test. Results: Centrally administered NO stimulators (L-arginine and SIN-1) were found to have immunopotentiating effect whereas, L- NAME (NOS inhibitor) and methylene blue (guanylyl cyclase inhibitor) did not produce any change in humoral immune response. Conclusion: L- arginine (NO precursor) and SIN-1 (NO donor) when administered icv produced an increase in the anti-SRBC antibody titre, while L-NAME and methylene blue (NO inhibitors) did not alter this humoral immune response.


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