IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 2672 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded501    
    Comments [Add]    

Recommend this journal


Year : 2000  |  Volume : 32  |  Issue : 5  |  Page : 309-312

Pharmacodynamic evaluation of transdermal drug delivery system of glibenclamide in rats

Correspondence Address:
S Sridevi

Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

Objective: To develop acrylate based transdermal drug delivery system (TDDS) for glibenclamide and evaluate it for its pharmacodynamic performance in male Wistar rats. Methods: The drug embedded in a polymeric matrix of polymethyl methacrylate and ethylcellulose was evaluated for its hypoglycemic activity in normal and streptozotocin induced diabetic rats in comparison with its oral therapy. A glucose tolerance test (GTT) was conducted in oral, TDDS and control group. Results: TDDS significantly sustained the hypoglycemic activity for 24 hrs in normal rats when compared to oral administration where the effect declined after 8 hrs. In diabetic rats, normoglycemic levels were maintained for a period of 24 hrs after transdermal delivery, an effect comparable to that of oral glibenclamide. The GTT curve was inhibited in both the groups. However, the reduction was slow and sustained in case of TDDS when compared to oral administration where significant hypoglycemic response was observed in all the three studies performed. Conclusion: The transdermal system is effective in preventing the frequent hypoglycemic episodes encountered after oral glibenclamide administration.


Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer | Privacy Notice
Online since 20th July '04
Published by Wolters Kluwer - Medknow