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Year : 2000  |  Volume : 32  |  Issue : 5  |  Page : 294-299

Antiobesity effect a polyherbal formulation, OB-200G in female rats fed on cafeteria and atherogenic diets

Correspondence Address:
Kaur Gurpreet

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Source of Support: None, Conflict of Interest: None

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Objective: To study the antiobesity effect of OB-200G, a polyherbal formulation in female Wistar rats fed on cafeteria and atherogenic diets. Methods: Female rats were fed cafeteria diet (highly palatable, energy rich animal diet that includes a variety of human snack foods) and atherogenic diet for 40 days. OB-200G was administered in a dose of 400 mg/kg, p.o., twice a day to the drug treatment groups. The effect of OB-200G on following parameters was recorded - body weight, rectal temperature, locomotor activity and various biochemical parameters like serum glucose, total cholesterol and triglyceride levels. Results: There was a significant (p < 0.05) reduction in body weight, increase in body temperature, locomotor activity and serum glucose levels after treatment with OB-200G in cafeteria diet and atherogenic diet fed rats. Treatment with OB-200G also significantly (p < 0.05) decreased total cholesterol in rats fed with atherogenic diet. Conclusion: OB-200G, a polyherbal formulation exhibited antiobesity effect in cafeteria and atherogenic diet fed rats.


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