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Year : 2000  |  Volume : 32  |  Issue : 5  |  Page : 288-293

Hepatoprotective and toxicological evaluation of Andrographis paniculata on severe liver damage

Correspondence Address:
Trivedi Neha

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Source of Support: None, Conflict of Interest: None

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Objectives: To study the hepatoprotective effect of aqueous extract of Andrographis paniculata (AP) on hexachlorocyclohexane (BHC) induced severe liver damage in Swiss male mice. Methods: The aqueous extract of Andrographis paniculata was given orally to the animals with liver damage induced by hexachlorocyclohexane (BHC). The hepatoprotective activity was monitored by estimating serum ALT & AST and other parameters like alkaline phosphatase, (-Glutamyl transpeptidase, glutathione and lipid peroxidase. Results: Aqueous extract of Andrographis paniculata inhibited BHC induced liver toxicity in Swiss male mice as assessed by the biochemical values. Conclusions: Aqueous extract of Andrographis paniculata has significant hepatoprotective activity.


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