| RESEARCH PAPER
|Year : 2000 | Volume
| Issue : 3 | Page : 231-234
Investigation into the pharmacological basis for some of the folkloric uses of Bonny light crude oil in Nigeria
OE Orisakwe, DD Akumka, OJ Afonne, KS Gamanniel
Objective: The effects of Bonny light crude oil on the smooth and skeletal muscles contraction and pain were investigated.
Methods: Analgesic effect of Bonny light crude oil was tested in mice using acetic acid (0.75%)- induced writhing model. Its effects on histamine-, and Ach-induced smooth muscle contraction were studied in guinea pig ileum. The effects of crude oil on Ach-induced contraction of rat duodenum and frog rectus abdominis muscle were also studied.
Results: The crude oil caused complete inhibition of histamine - induced smooth muscle contraction, while producing only a partial inhibition of the acetylcholine - induced contraction. It had no effects on the acetylcholine-induced skeletal muscle contraction, but showed good analgesic effect comparable to aspirin.
Conclusion: The Bonny light crude oil possesses inhibitory action on smooth muscle contraction induced by histamine, and analgesic property.
O E Orisakwe
Source of Support: None, Conflict of Interest: None