| RESEARCH PAPER
|Year : 2000 | Volume
| Issue : 3 | Page : 202-205
Cardioprotective actions of enalapril and lisinopril on ischemia-reperfusion induced myocardial infarction in normal and salt loaded rats
A Annapurna, Babu M Rajendra, D Ranganayakulu
Objective: To evaluate the cardioprotective actions of two angiotensin converting enzyme (ACE) inhibitors, enalapril and lisinopril on myocardial infarction in normal and salt loaded rats.
Methods: Myocardial infarction was produced by occlusion of left coronary artery for 30 minutes followed by 4 hours of reperfusion. Infarct size was measured by using triphenyl tetrazolium chloride (TTC) stain method.
Results: Infarct size, expressed as percent myocardial infarction (PMI) was found to be 34.84 with untreated control animals, whereas PMI was significantly reduced to 14.78 and 13.54 with enalapril (3 mg/kg) and lisinopril (3 mg/kg) pretreatment respectively. In salt loaded animal groups, PMI was found to be 37.20 with control untreated and reduced to 13.41 with enalapril pretreatment (3 mg/kg) and 13.19 with lisinopril pretreatment (3 mg/kg) respectively.
Conclusion: The results suggest a possible cardioprotective role for ACE inhibitors.
Source of Support: None, Conflict of Interest: None