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Year : 2000  |  Volume : 32  |  Issue : 3  |  Page : 202-205

Cardioprotective actions of enalapril and lisinopril on ischemia-reperfusion induced myocardial infarction in normal and salt loaded rats

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A Annapurna

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Source of Support: None, Conflict of Interest: None

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Objective: To evaluate the cardioprotective actions of two angiotensin converting enzyme (ACE) inhibitors, enalapril and lisinopril on myocardial infarction in normal and salt loaded rats. Methods: Myocardial infarction was produced by occlusion of left coronary artery for 30 minutes followed by 4 hours of reperfusion. Infarct size was measured by using triphenyl tetrazolium chloride (TTC) stain method. Results: Infarct size, expressed as percent myocardial infarction (PMI) was found to be 34.84 with untreated control animals, whereas PMI was significantly reduced to 14.78 and 13.54 with enalapril (3 mg/kg) and lisinopril (3 mg/kg) pretreatment respectively. In salt loaded animal groups, PMI was found to be 37.20 with control untreated and reduced to 13.41 with enalapril pretreatment (3 mg/kg) and 13.19 with lisinopril pretreatment (3 mg/kg) respectively. Conclusion: The results suggest a possible cardioprotective role for ACE inhibitors.


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