| RESEARCH PAPER
|Year : 2000 | Volume
| Issue : 3 | Page : 198-201
Protective effect of Abana ®, a poly-herbal formulation, on isoproterenol-induced myocardial infarction in rats
Sasikumar C Sheela, Devi CS Shyamala
Objective: To find out the possible role of lipid peroxidation and glutathione in the pathogenesis of myocardial infarction and the protective role of Abana, a polyherbal drug.
Methods: The effect of Abana pretreatment (75 mg /100 g ) for a period of 60 days on isoproterenol (20 mg/100g s.c. twice at an interval of 24 hrs) induced lipid peroxidation was studied in rats. Marker enzymes levels such as creatine kinase, lactate dehydrogenase, alanine transaminase and aspartate transaminase were assessed in serum and heart homogenate. Glutathione content and lipid peroxide level were also estimated.
Results: In isoproterenol administered rats, a significant decrease was observed in the levels of marker enzymes in the heart with a corresponding increase in their levels in serum. Lipid peroxide level measured in terms of "TBA reactants" increased significantly in serum and heart. In rats pretreated with Abana, the alterations observed in the marker enzymes and lipid peroxide level were minimum on isoproterenol administration, and the levels were retained at near normal values.
Conclusion: Abana pretreatment may offer protection in experimental myocardial infarction induced by isoproterenol.
Sasikumar C Sheela
Source of Support: None, Conflict of Interest: None