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Year : 2000  |  Volume : 32  |  Issue : 2  |  Page : 94-101

Antidotes to cyanide poisoning: present status

Correspondence Address:
R Bhattacharya

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Source of Support: None, Conflict of Interest: None

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Cyanide is ubiquitously present in the environment. It is considered as a potent suicidal, homicidal, genocidal and chemical warfare agent. Cyanide toxicity is mediated through inhibition of cellular respiration, but its other complex toxic manifestations are also well documented. There are a number of antidotes available for cyanide poisoning ( e.g. sodium nitrite, 4-dimethyl aminophenol, sodium thiosulphate, etc.), however, there is still uncertainty about their safety, efficacy and correct indication for use. This review provides a comprehensive account of toxicology of cyanide and the present status of various antidotes employed clinically or pursued experimentally.


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