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Year : 2000  |  Volume : 32  |  Issue : 1  |  Page : 7-10

Effect of DLH-721A and DLH-721B (polyherbal formulations) on rat mesenteric mast cell degranulation

Correspondence Address:
K Padmalatha

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Source of Support: None, Conflict of Interest: None

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Objective: To study the antianaphylactic effect of DLH-721A and DLH-721B (herbal formulation) on the rat mesenteric mast cells. Methods: The study was carried out on the rat mesenteries sensitised with sheep serum to induce mast cell degranulation. Mesenteries pretreated with prednisolone, disodium cromoglycate, DLH-721A and DLH-721B were analysed for the mast cell degranulation during the anaphylactic reactions. Results: Treatment with DLH-721A and DLH-721B showed beneficial effect on degranulation of actively and passively sensitised mesenteric mast cells. The protective effect was comparable with that of prednisolone and disodium cromoglycate. Conclusion: DLH-721A and DLH-721B may have antianaphylactic activity on the rat mesenteric mast cells.


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