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Year : 2000  |  Volume : 32  |  Issue : 1  |  Page : 41-86

Abstracts of research papers presented in International Congress on Frontiers in Pharmacology and Therapeutics in 21 st Century, New Delhi, 1999. (Part-1\2)

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Objective: To investigate the hypolipidemic effect of fenugreek in hypercholesterolaemic patients. Methods: Fenugreek ( Trigonella foenum graecum) seeds (FG) were powdered and extracted with hexane to remove its lipid content and alcohol to remove the saponins. This powder was used for the study. The patients were divided into 3 groups of 6 each as follows: Group I received placebo 50 gm (rice powder and Bengal gram powder in equal measures); Group II -placebo 25 gm + FG 25 gm and Group III -FG 50 gm. Patients were directed to take each 50 gm pack orally before lunch and dinner every day for 20 days. Blood samples were collected after overnight fasting on 0, 10th and 20th days during test period and estimated for lipid profile. Results: There were no significant changes in lipid profile of group I patients. In groups II and III serum cholesterol, triglycerides and VLDL levels were significantly decreased when compared to group I. Conclusion: FG powder given orally before food at 25 and 50 gm twice a day may have hypolipidemic effect in hypercholesterolaemic patients.


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