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Year : 2000  |  Volume : 32  |  Issue : 1  |  Page : 31-33

Facilitation of behavioural depression by antiepileptic drugs

Correspondence Address:
S K Srivastava

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Source of Support: None, Conflict of Interest: None

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Objective: To investigate the effect of certain antiepileptic drugs on behavioural depression in mice. Methods: The study was conducted in Swiss albino mice of either sex weighing 25-35 g in behavioural despair test. The mice were acutely treated with carbamazepine (20 and 40 mg/kg, p.o.) sodium valproate (100 and 200 mg/kg, p.o.) and gabapentin (3, 10 and 30 mg/kg, i.p.) and effect of these drugs were observed 60 min after the drug treatment. In each set up of experiment duration of immobility in last 5 min (during 6 min session) was recorded and analysed to find out the effect on depression. Results: Carbamazepine, sodium valproate and gabapentin in higher doses significantly and dose dependently increased the duration of immobility in behavioural despair test. Conclusion: Carbamazepine, sodium valproate and gabapentine facilitates depression in the above animal model.


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