| SHORT COMMUNICATION
|Year : 2000 | Volume
| Issue : 1 | Page : 31-33
Facilitation of behavioural depression by antiepileptic drugs
Objective: To investigate the effect of certain antiepileptic drugs on behavioural depression in mice.
Methods: The study was conducted in Swiss albino mice of either sex weighing 25-35 g in behavioural despair test. The mice were acutely treated with carbamazepine (20 and 40 mg/kg, p.o.) sodium valproate (100 and 200 mg/kg, p.o.) and gabapentin (3, 10 and 30 mg/kg, i.p.) and effect of these drugs were observed 60 min after the drug treatment. In each set up of experiment duration of immobility in last 5 min (during 6 min session) was recorded and analysed to find out the effect on depression.
Results: Carbamazepine, sodium valproate and gabapentin in higher doses significantly and dose dependently increased the duration of immobility in behavioural despair test.
Conclusion: Carbamazepine, sodium valproate and gabapentine facilitates depression in the above animal model.
S K Srivastava
Source of Support: None, Conflict of Interest: None