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Year : 2000  |  Volume : 32  |  Issue : 1  |  Page : 28-30

Therapeutic drug monitoring of antiepileptic drugs-a preliminary experience

Correspondence Address:
S K Garg

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Source of Support: None, Conflict of Interest: None

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Objective: To carry out a retrospective analysis of therapeutic drug monitoring (TDM) data for phenytoin (DPH) and carbamazepine (CBZ) and to assess its utility to the prescribing physician. Methods: 239 patients on DPH or CBZ were put into four categories based upon plasma drug concentration i.e. therapeutic, subtherapeutic, toxic and not detectable. Clinical records were examined to see the follow up action taken. Results: In CBZ group 93 patients (75.6%) had therapeutic, 22 (17.9%) subtherapeutic, 3 (2.4%) toxic and 5 (4.1%) no detectable levels while in DPH group, 38 (32.8%) had therapeutic, 63 (54.3%) subtherapeutic, 12 (10.3%) toxic and 3 (2.6%) no detectable levels of the drug. Conclusion: TDM of Phenytoin and Carbamazepine can help the physician in optimizing the dose for a better seizure control.


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