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Year : 2000  |  Volume : 32  |  Issue : 1  |  Page : 25-27

Study on the action of captopril: A sulfhydryl donor on rodent ulcer

Correspondence Address:
Dau Harminder

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Source of Support: None, Conflict of Interest: None

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Objective: To evaluate ulcero-protective property of captopril-a sulfhydryl donor in rats. Methods: The study was done in rats by inducing gastric ulcer by oxyphenbutazone, 0.6 M hydrochloric acid and restrain stress and the effect of different doses of captopril alone or/and omeprazole was studied. Effect of paracetamol-a depleter of glutathione of stomach was observed over captopril and/or omeprazole. Results: Captopril produced dose dependent protection against experimentally induced gastric ulcer in rats. Its ulcero-protective effect was enhanced by omeprazole. Paracetamol reduced the protection offered by both the agents alone and in combination. Conclusion: Captopril produced dose dependent protection against experimentally induced gastric ulcer. Its protective effect was enhanced by omeprazole and reduced by paracetamol suggesting a possible involvement of sulfhydryl group of captopril in ulcer protection.


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