| RESEARCH PAPER
|Year : 2000 | Volume
| Issue : 1 | Page : 25-27
Study on the action of captopril: A sulfhydryl donor on rodent ulcer
Dau Harminder, CK Chauhan, S Shahani
Objective: To evaluate ulcero-protective property of captopril-a sulfhydryl donor in rats.
Methods: The study was done in rats by inducing gastric ulcer by oxyphenbutazone, 0.6 M hydrochloric acid and restrain stress and the effect of different doses of captopril alone or/and omeprazole was studied. Effect of paracetamol-a depleter of glutathione of stomach was observed over captopril and/or omeprazole.
Results: Captopril produced dose dependent protection against experimentally induced gastric ulcer in rats. Its ulcero-protective effect was enhanced by omeprazole. Paracetamol reduced the protection offered by both the agents alone and in combination.
Conclusion: Captopril produced dose dependent protection against experimentally induced gastric ulcer. Its protective effect was enhanced by omeprazole and reduced by paracetamol suggesting a possible involvement of sulfhydryl group of captopril in ulcer protection.
Source of Support: None, Conflict of Interest: None