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Year : 1999  |  Volume : 31  |  Issue : 6  |  Page : 440-441

Bioassay of acetylcholine with horizontal strips of rat fundus

Correspondence Address:
Sa SB De

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Source of Support: None, Conflict of Interest: None

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Objective: To find out the suitability of horizontal strips of rat fundus for bioassay of acetylcholine (ACh). Methods: Dose response curves to ACh were obtained using a horizontal strip of rat fundus suspended in Tyrode solution. The effects of histamine (H) and 5-hydroxytryptamine (5-HT) were also studied. Results: Horizontal strips of rat fundus were stable over a long period of time (more than 6 hrs) showing reproducible responses to Ach with good discrimination between doses. It did not respond to H and 5-HT. Thus it was specific to ACh, the sensitivity being 10 -8 g/ml. Conclusion: The modified preparation of rat fundus described by us is simple and satisfies the prerequisites for the bioassay of ACh.


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