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Year : 1999  |  Volume : 31  |  Issue : 6  |  Page : 434-436

Haloperidol inhibits (-) bicuculline-induced seizures and bicuculline potentiates haloperidol-induced catalepsy in mice

Correspondence Address:
R S Somani

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Source of Support: None, Conflict of Interest: None

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Objective: To investigate the interaction between haloperidol and bicuculline in seizure and catalepsy models of mice. Methods: The effect of different doses of bicuculline (0.7-2.1 mg/kg, i.p.) was studied on severity of haloperidol (1 mg/kg, i.p.)-induced catalepsy using that Bar test and the effect of varying doses of haloperidol (1-3 mg/kg, i.p.) was studied on the onset of myoclonic spasm and clonic convulsions induced by bicuculline in mice. Results: Haloperidol-induced catalepsy was potentiated by bicuculline and bicuculline-induced seizures were inhibited by haloperidol. Conclusion: Haloperidol inhibited bicuculline-induced seizures probably by reducing the excitatory input to the cerebral cortex and bicuculline potentiated haloperidol-induced catalepsy by reducing dopaminergic transmission in substantia nigra.


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