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Year : 1999  |  Volume : 31  |  Issue : 6  |  Page : 427-430

Oxidative damage in mice liver induced by sodium valproate: Protection by melatonin

Correspondence Address:
Siddiqui MA Asif

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Source of Support: None, Conflict of Interest: None

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Objective: To study the possible protective effects of melatonin against sodium valproate induced hepatotoxicity in mice. Methods: Mice were treated with melatonin (15 mg/kg, i.p.), valproate (30 mg/kg, p.o.), or a combination of both in an acute and a chronic study schedule. After testing the effectiveness of the combination in the Increasing Current Electroshock Seizure (ICES) model of epilepsy, liver glutathione (GSH) and lipid peroxidation, and the serum aspartate transaminase (AST) & alanine transaminase (ALT) activities were estimated for studying the protection against valproate hepatotoxicity by melatonin. Results: Valproate produced significant depletion of GSH and increase in lipid peroxidation products in liver and AST-ALT activities in serum. These changes were effectively reversed by melatonin. Conclusion: Melatonin can effectively counter valproate hepatotoxicity on account of its strong antioxidant properties.


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