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Year : 1999  |  Volume : 31  |  Issue : 5  |  Page : 373-375

Effect of fresh juice and ethyl acetate extract of clerodendron colebrookianum leaves on serum and liver transaminase activity in rats

Correspondence Address:
Devi Rajlakshmi

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Source of Support: None, Conflict of Interest: None

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Objective: To study the effect of fresh juice (FJ) and ethyl acetate extract (EE) of Clerodendron colebrookianum (CC) leaves on glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) in the blood and liver of male Sprague Dawley rats. Methods: Three groups of rats each comprising of 10 animals were selected for this experiment. Group I served as control and the other two groups were orally administered with FJ and EE extracts respectively, upto a period of 28 days. The GOT and GPT were estimated on days 7, 14, 21 and 28 using an autoanalyser. Result: FJ treatment significantly reduced the SGOT level only. After EE administration SGPT was increased more than 9-10 fold over the respective control, while the SGPT declined significantly on days 7 and 14 of experimentation. Sustained elevation in the level of liver GPT was recorded in the EE treated animals while the liver GOT was found to be increased on days 7 and 14 but returned to control level on day 28. Conclusion: FJ and EE of CC leaves affect the transaminases levels, but no liver cell damage occurred in rats.


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